Bacterial DNA Mediated Protection from Systemic Lupus Erythematosus

Abstract Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with no known cure. Current therapies primarily rely on symptom control corticosteroids, however these carry many adverse effects. In recent decades, the gut microbiome has gained appreciation as major immunomodulator of disease. Toll-like receptor 9 (TLR9) to interact microbial DNA readily provided by microbiota. Polymorphisms TLR9 have been implicated in increased susceptibility SLE, and overexpression shown be protective mice. Agonization bacterial (bDNA) could provide passive immunity other conditions without side effects corticosteroids. We previously showed that vivoadministration bDNA was against mice, mechanism behind this protection unknown. vitrostimulation prone splenocytes production IL-10, potent anti-inflammatory cytokine, along an increase IL-6, cytokine induce proliferation IL-10 producing B cells antibody plasma cells. This phenomenon dependent expression, but expression either or dendritic sufficient IL-10. However, activation may cause less dramatic which lead more beneficial, profile potential therapeutic. Our results suggest possible avenue management avoids use Future studies will focus cell targeted delivery promotes effect increasing IL-6.